Intense exercise stress may trigger Corynebacterium kutscheri infection in Sprague-Dawley rats

In this study, Corynebacterium kutscheri infection was reported in Sprague-Dawley rats that were stressed due to intense exercise during an experimental study. Weight loss, indifference the environment, fluffy feathers, and hunched posture observed affected rats. The lungs contained numerous, randomly distributed, variably sized, slightly raised, cream-colored caseopurulent foci. There occasional weak adhesions between lung lobes adjacent costal pleura. Multifocal coalescing necro-suppurative pneumonia with intralesional scattered large colonies of bacteria histopathologically. Adjacent pulmonary parenchyma, interalveolar hypercellularity, type II pneumocyte hyperplasia, fibrinonecrotic vasculitis, pleuritis observed. Brown-Breen staining revealed gram-positive cocobacilli lesion areas. Furthermore, cardiac lesions which atria more severely than ventricles identified. This characterized by thickening epicardium infiltrates macrophages admixed neutrophils. rats, also involved underlying myocardium. Bacterial culture yielded positive growth for C. kutsheri from lesioned organ. Polymerase chain reaction used confirm presence genetic material kutscheri. As a result, it infected stress. Periodic controls have been suggested units where animals are both because its negative effects on results studies be conducted zoonotic nature.